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When I first started taking Hydroxyurea it made me a little sick. Yet, after about 2 weeks I noticed a slight increase in energy and went from having a hospitalization crisis every 2-3 months to about ONCE a year. I still take pain meds for the smaller pains but my lifestyle had gotten MUCH better. I would recommend it to any person with sickle cell.
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I've been taking this medicine for about six weeks or so and the problem so far has been that my nail beds are turning black. A little freaked out right now but surprisingly I've been feeling a lot better.

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Among several agents that lead to pharmacologic induction of HbF in patients with SCA, hydroxyurea has emerged as an exciting therapeutic agent because of its ease of oral administration, modest toxicity profile, predictable laboratory efficacy for increasing percentage HbF and reducing hemolysis, and proven clinical efficacy for preventing acute vaso-occlusive events.

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