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It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and a reduced insulin resistance, and vice versa.

Insulin and IGF-1 act synergistically with FSH to enhance oestrogen production by granulosa cells and with LH to enhance androgen production by thecal stromal cells.

Patients should meet with a professional dietitian to plan an individualized diet within the general guidelines that takes into consideration their own health needs.

Due to the fact that insulin resistance is rarely measured clinically, other criteria have been adopted to identify individuals who might be insulin resistant and possess the MS.

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In part, TG synthesis is promoted by ASP-stimulated increases in diglycerol acyltransferase activity and glucose uptake into adipocytes, and these effects may be mediated by activation of specific adipocyte protein kinases, for example PKC ().

Some diets are based on this concept, assuming that consumption of low-GI food is less likely to result in insulin resistance and obesity, however, small to moderate amounts of simple sugars (i.

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Park and Yetley () was written, the use of crystalline fructose had just been expanded to the general food supply.

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In general, studies have shown that rapidly acting analogues are superior to regular insulin for lowering glycosylated hemoglobin levels in patients who receive insulin by continuous subcutaneous infusion.

Leptin gained increasing attention in the late 1990s and this work fashioned leptin into a central regulator of feeding and energy homeostasis ().

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Recently increased intramyocellular lipid and reduced mitochondrial phosphorylation has been reported in lean insulin-resistant offspring of patients with Type 2 diabetes, suggesting subtle mitochondrial dysfunction may be more widespread in this disorder.

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Safety of once-daily insulin detemir in patients with type 2 diabetes treated with oral hypoglycemic agents in routine clinical practice (在常规临床实践中使用口服降糖药治疗的2型糖尿病患者每日一次使用地特胰岛素治疗的安全性).

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In both disorders, tissues such as muscle, fat and liver become less responsive or resistant to insulin.

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SMBG is an effective way to evaluate short-term glycemic control.

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There may be hypoglycaemic episodes between meals and at night; again, use of fast-acting analogues instead of soluble insulin may reduce this problem.

Two other enzymes may also contribute to a circulating H 2S pool, namely 3-mercaptopyruvate sulfurtransferase and cysteine aminotransferase, both of which are active in the brain and the endothelium.

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Even when treated with insulin shots, moderately high sugar levels over the long term can damage the eyes, heart, kidneys and nerves.

When you become sick with a cold, fever, or the flu, you need to take your usual insulin dose, even if you feel too ill to eat.

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