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On the basis of this result, several treatment guidelines currently recommend that the data from our study be considered in selecting NRTIs for patients with high HIV-1 RNA levels who have not received antiretroviral treatment.

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Finally, remember that all treatment decisions should be made in partnership with your health care provider.

The American Association for the Study of Liver Disease recommends that patients who are HBeAg-positive with moderate or severe chronic hepatitis and raised aminotransferases (more than twice the upper limit of normal) should be offered either: (i) a 4-6 month course of interferon (10 MU thrice weekly); or (ii) a 1-year course of lamivudine (100 mg once a day if no HIV infection); or (iii) a 1-year course of adefovir (10 mg once a day).

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ICERs of branded compared with 3-pill, generic-based ART were substantially higher at every combination of 24-week efficacy and price reduction for generic-based ART ().

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The mechanism of this drug is activation via a viral protein kinase HCMV UL97 and subsequent phosphorylation by cellular kinases.

Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

Cases of worsening liver disease have been reported when lamivudine is stopped in patients with both HIV and HBV infection.

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M184V mutation reduces “viral fitness”, because of the finding that continued lamivudine treatment causes the HIV viral load to rebound but at a much lower level, and that withdrawal of lamivudine results in a higher viral load rebound with rapid loss of the M184V mutation; GSK therefore argued that there may be benefit in continuing lamivudine treatment even in the presence of high level resistance, because the resistant virus is “less fit”.

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Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue Lamivudine tablets taking into consideration the importance of continued hepatitis B therapy to the mother and the known benefits of breastfeeding.

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Viral reactivation in hepatitis B surface antigen (HBsAg) carriers undergoing immunosuppressive therapy is well documented.

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